The M25 will be closed both ways from 9 pm tonight until 6 am on Monday morning between junction 10 for Wisley and junction 11 for Chertsey.
The full closure is needed for demolition works and gantry installation. It is the first time there has been a scheduled daytime shutdown of all lanes on the M25 since it opened in 1986.
National Highways say that motorists will experience severe delays and should avoid the area entirely.