In all, 307 knives were recovered from amnesty bins, knife sweeps or other activities in West Sussex, while in East Sussex, 200 knives were recovered.
In Brighton and Hove, 1,000 students, 52 retailers and 32 taxi drivers were engaged by officers.
A total of 47 knives were also seized in the city.
Police said the primary focus of the operation was on patrols in hotspot locations and working to divert young people away from knife crime.
Police and Crime Commissioner for Sussex Katy Bourne said knife surrender bins, public engagement and education were needed to tackle knife crime effectively.
“Carrying a weapon can lead to catastrophic, life-changing consequences, and it isn’t worth it – lose the knife, not a life,” she said.
“The work with partners, schools and relevant organisations happens not just during this week but throughout the year, and is critical to making Sussex an uncomfortable place for knife carriers.”
Ch Insp Loader said Sussex is a “safe place,” where knife crime related incidents are “substantially below the national average” by area.
“Despite this, there is always room for improvement,” he said.
BBC